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Asian Journal of Urology, 2023, 10(4): 453-460    doi: 10.1016/j.ajur.2023.08.004
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Right versus left fully robotic live donor nephrectomy and open kidney transplantation: Does the laterality of the donor kidney really matter?
Brianna Rucha,Deki Tseringa,Chandra Bhatib,Dhiren Kumara,Muhammad Saeeda,Seung Duk Leea,Aamir Khana,Daisuke Imaia,David Brunoa,Marlon Levya,Adrian Cotterella,Amit Sharmaa*()
aHume-Lee Transplant Center, Virginia Commonwealth University, Richmond, VA, USA
bDivision of Transplant Surgery, University of Maryland, Baltimore, MD, USA
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Abstract: 

Objective: Robotic-assisted live donor nephrectomy (LDN) is being gradually adopted across transplant centers. The left donor kidney is preferred over right due to anatomical factors and ease of procurement. We aimed to study donor and recipient outcomes after robotic procurement and subsequent open implantation of right and left kidneys.

Methods: All fully robotic LDNs and their corresponding open kidney transplants performed at our center between February 2016 and December 2021 were retrospectively analyzed.

Results: Out of 196 robotic LDN (49 [right] vs. 147 [left]), 10 (5.1%) donors had intra-operative events (6.1% [right] vs. 4.8% [left], p=0.71). None of the LDN required conversion to open surgery. The operative times were comparable for the two groups. Nausea (13.3%) was the most common post-operative complication. There was no mortality in either LDN group. Herein, we report our outcomes on 156 recipients (39 right and 117 left allografts) excluding robotic implants, exports, and pediatric recipients. There were no significant differences between right and left kidney recipients with respect to 1-year post-transplant patient survival (100.0% vs. 98.1%, p=0.45) or graft survival (93.9% vs. 97.1%, p=0.11), or delayed graft function (7.7% vs. 5.1%, p=0.55).

Conclusion: Non-hand-assisted robotic live donor nephrectomies can be safely performed with excellent outcomes. Right LDN was not associated with higher incidence of complications compared to left LDN. Open implantation of robotically procured right renal allografts was not associated with higher risk of recipient complications.

Key words:  Robotics    Laparoscopy    Donor nephrectomy    Complication    Renal transplant    Outcome
收稿日期:  2023-02-06      修回日期:  2023-07-21      接受日期:  2023-08-16      出版日期:  2023-10-20      发布日期:  2023-11-13      整期出版日期:  2023-10-20
引用本文:    
. [J]. Asian Journal of Urology, 2023, 10(4): 453-460.
Brianna Ruch, Deki Tsering, Chandra Bhati, Dhiren Kumar, Muhammad Saeed, Seung Duk Lee, Aamir Khan, Daisuke Imai, David Bruno, Marlon Levy, Adrian Cotterell, Amit Sharma. Right versus left fully robotic live donor nephrectomy and open kidney transplantation: Does the laterality of the donor kidney really matter?. Asian Journal of Urology, 2023, 10(4): 453-460.
链接本文:  
http://www.ajurology.com/CN/10.1016/j.ajur.2023.08.004  或          http://www.ajurology.com/CN/Y2023/V10/I4/453
Characteristic Right LDN (n=49) Left LDN (n=147) p-Value
Age, mean±SD, year 43.8±13.3 41.5±11.8 0.23
Females, n (%) 33 (67.3) 89 (60.5) 0.39
BMI, mean±SD, kg/m2 27.0±4.2 27.3±4.5 0.69
Race, % -
Caucasian 73.5 61.9
African American 24.4 31.9
Others 2.1 6.2
Employment, % -
Full-time 83.7 80.3
Unemployed 0 6.8
Other 16.3 12.9
Relationship to donor, % -
Relative 30.6 42.9
Spouse 30.6 12.2
Friend 30.6 37.4
Altruism 8.2 7.5
  
Characteristic Right LDN (n=49) Left LDN (n=147) p-Value
da Vinci robotic assist, n (%)
Xi 40 (81.6) 112 (76.2) 0.43
Si 9 (18.4) 35 (23.8) 0.43
Operative time, mean±SD, min 186.8±32.5 195.0±40.9 0.18
Blood loss, mean±SD, mL 41.4±63.8 35.0±29.4 0.74
Renal anatomy, n (%)
Two arteries 8 (16.3) 28 (19.0) 0.67
Two veins 10 (20.4) 7 (4.8) 0.001
Hospital stay, mean±SD, day 3.4±0.8 3.3±0.8 0.33
Serum creatinine, mean±SD, mg/dL
Pre-donation 0.82±0.16 0.85±0.17 0.20
2-week post-donation 1.25±0.27 1.32±0.29 0.14
6-month post-donation 1.21±0.22 1.23±0.24 0.69
eGFR, mean±SD, mL/min
Pre-donation 98.6±16.4 100.3±15.3 0.53
2-week post-donation 63.0±15.6 61.0±13.6 0.48
6-month post-donation 65.5±16.3 64.9±14.2 0.47
  
Complication Right LDN (n=49) Left LDN (n=147) Intervention Clavien-Dindo grade
Intra-operative 3 (6.1) 7 (4.8)
Renal artery stump bleeding 1 (2.0) 1 (0.7) Clip over staple line -
Colon mesentery tear 0 2 (1.4) Mesenteric defect clipped -
Gallbladder perforation 1 (2.0) 0 Gallbladder suture repaired -
Ureter transected distally 1 (2.0) 0 Used without sequelae -
Renal subcapsular hematoma 0 2 (1.4) No sequelae -
Chyle leak 0 2 (1.4) Lymph leak clipped -
Post-operative 14 (28.6) 35 (23.8)
Nausea 9 (18.4) 17 (11.6) Anti-emetics I
Atelectasis 2 (4.1) 3 (2.0) Chest physiotherapy I
Incisional pain 0 3 (2.0) Oral narcotics I
Stridor 0 1 (0.7) Observation I
Reflux esophagitis 0 1 (0.7) Anti-acid cocktail I
Rhabdomyolysis 0 1 (0.7) Fluids (i.v.) I
Testicular swelling 0 2 (1.4) Observation I
Hypotension 1 (2.0) 0 Fluids (i.v.) I
Narcotic overdose 0 1 (0.7) Narcan for reversal II
Severe constipation 1 (2.0) 0 Enemas II
Meralgia paresthetica 0 1 (0.7) Neurectomy III
Surgical site infection 0 1 (0.7) Antibiotics II
COVID-19 0 1 (0.7) Supportive care I
Spontaneous pneumothorax 0 1 (0.7) Chest tube III
Pulmonary embolus 1 (2.0) 0 Anticoagulation II
Chylous ascites 0 1 (0.7) Diet, paracentesis III
Internal hernia 0 1 (0.7) Operative repair III
  
Parameter Right kidney recipient (n=39) Left kidney recipient (n=117) p-Value
Age, mean±SD, year 47.7±15.1 50.2±15.3 0.38
BMI, mean±SD, kg/m2 28.6±6.1 29.2±6.0 0.63
Female, n (%) 16 (41.0) 63 (53.8) 0.17
Prior dialysis, n (%) 27 (69.2) 84 (71.8) 0.76
Prior kidney transplant, n (%) 5 (12.8) 10 (8.5) 0.43
Female to male donation, n (%) 12 (30.8) 27 (23.1) 0.34
Blood loss, mean±SD, mL 173.5±167.9 150.6±163.9 0.87
Cold ischemia time, mean±SD, min 60.4±48.2 68.4±61.1 0.53
Warm ischemia time, mean±SD, min 33.0±13.3 31.3±6.0 0.57
  
Outcome Right kidney recipient (n=39) Left kidney recipient (n=117) p-Value
Hospital stay, mean±SD, day 5.1±1.8 5.2±3.0 0.85
Serum-creatinine at 1-year, mean±SD, mg/dL 1.29±0.48 1.42±0.38 0.12
Patient survival at 1-year, % 100.0% (33/33) 98.1% (103/105)a 0.45
Graft survival at 1-year, % 93.9% (31/33)b 97.1% (102/105)a 0.11
Complication, n (%)
Early graft loss 2 (5.1)b 1 (0.9)a 0.09
Delayed graft function 3 (7.7) 6 (5.1) 0.55
Acute rejection 2 (5.1) 2 (1.7) 0.24
Urinary infections 4 (10.3) 7 (6.0) 0.37
Renal artery stenosis 1 (2.6) 0 -
Vascular thrombosis 1 (2.6) 1 (0.9) 0.41
Re-exploration for bleeding 0 2 (1.7) -
Renal torsion 1 (2.6) 0 -
Ureteral stricture 1 (2.6) 1 (0.9) 0.41
Wound seroma 0 4 (3.4) -
Lymphocele 0 4 (3.4) -
DVT/PE 1 (2.6) 3 (2.6) 1.00
Ileus 1 (2.6) 1 (0.9) 0.41
Myocardial infarction 0 3 (2.6) -
  
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