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Phalloplasty following penectomy for penile cancer |
Wai Gin Leea,b,*( ),A. Nim Christophera,b,David J. Ralpha,b
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aUniversity College London Hospital, London, United Kingdom bSt Peter's Andrology, London, United Kingdom |
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Abstract Objective: Penile reconstruction or phalloplasty following penectomy can be offered where the functional penile length is inadequate for a man to void while standing or to have sexual intercourse. Phalloplasty is usually staged due to the complex surgical techniques required. This narrative review describes the technical concepts and summarises the contemporary outcomes following phalloplasty in this challenging cohort. Methods: A retrospective review of the English literature was performed between January 1946 till November 2021. The data were synthesised and complemented by the expert opinion of the authors with 20 years of experience in this field. The flaps are ideally designed with an integrated urethra or alternatively, a further free flap urethroplasty can be offered. Phalloplasty is further complicated following penectomy by scarring from the previous surgery and the potential loss of structures that would normally be present at the recipient site. Results: There are limited published data with a total of 19 men recorded in the literature. Only the radial artery forearm free flap and anterolateral thigh flap have been described in this cohort of patients. Functional outcomes including standing micturition, sensation in the neophallus, and the ability to orgasm are good. Overall quality of life and satisfaction was also good despite the high risk for long-term complications of the neophallus and donor site. Conclusion: Phalloplasty following penectomy requires microsurgical transfer of a free flap or a pedicled flap to reconstruct a neophallus. An erectile device is inserted at a later stage to facilitate sexual intercourse, if desired. Surgical scarring from penectomy and the potential loss of vasculature that would normally be present at the recipient site may further complicate reconstruction. Surgical and functional outcomes are acceptable based on the limited published experience to date.
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Received: 11 December 2021
Available online: 20 October 2022
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Corresponding Authors:
Wai Gin Lee
E-mail: waigin.lee@nhs.net
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Flap | Sensation | Donor site morbidity | Colour match | Single stage urethraa | Bulky | RFF | Best | Visible | No | Yes | No | ALT | Yes | Hidden | Yes | Some | Yes | MLD | Poor | Hidden | No | No | Yes | Abdominal | Variable | Hidden | Yes | No | Yes |
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Comparison of functional and aesthetic outcomes of commonly used flaps for phalloplasty.
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Author | Patient, n | Age, year | Primary surgery | Inguinal lymph node dissection | Flap used | Integrated urethra | Garaffa et al. [6] | 15 | 44 (39-54)a | Total penectomy | Yes (n=12) | RFF | Yes | Akino et al. [7] | 1 | 16 | Total penectomy | No | RFF | Yes | Hoebeke et al. [8] | 1 | 16 | Total penectomy | No | RFF | Yes | Lee et al. [9] | 1 | 63 | Total penectomy | No | ALT | Yes | Sasaki et al.[10] | 1 | 51 | Partial penectomy | No | RFF | Yes |
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Summary of papers reporting phalloplasty following penile cancer treatment.
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Single cylinder device prepared with Dacron? cap in place.
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Study | Median follow-up, month | Adverse event | Standing micturition, % | Sensation, % | Orgasm, % | Satisfied, % | Lee et al. [9] | 12 | Phallus (n=2) | 100 | 100 | 100 | 100 | Hoebeke et al. [8] | 12 | Nil | 100 | NR | NR | 100 | Garaffa et al. [6] | 20 (range 1-68) | Phallus (n=14); donor site (n=7) | 100 | 87 | NR | 100 | Akino et al. [7] | 84 | Nil | 100 | 100 | 100 | 100 | Sasaki et al. [10] | 48 | Nil | 100 | 100 | 100 | 100 |
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Surgical and functional outcomes following phalloplasty for total penectomy.
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The neophallus deflated.
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The neophallus inflated.
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