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Robotic-assisted retroperitoneal lymph node dissection for stage II testicular cancer |
George McClintocka,*( ),Ahmed S. Goolama,Don Pererab,Ryan Downeyb,Scott Lesliea,c,Peter Grimisonc,d,Henry Wooa,c,Peter Fergusonc,Nariman Ahmadia
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aDepartment of Urology, Chris O'Brien Lifehouse, Sydney, NSW, Australia bDepartment of Anaesthesia, Chris O'Brien Lifehouse, Sydney, NSW, Australia cThe University of Sydney, Sydney, NSW, 2006, Australia dDepartment of Medical Oncology, Chris O'Brien Lifehouse, Sydney, NSW, Australia |
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Abstract Objective: To evaluate the perioperative as well as early oncological outcomes of patients undergoing robotic retroperitoneal lymph node dissection for treatment of testicular cancer. Methods: We conducted a prospective consecutive case series of patients undergoing robotic assisted retroperitoneal lymph node dissection for metastatic testicular cancer between May 2018 and July 2021 at our institution. Data were collected on patient and tumour characteristics, intraoperative and postoperative parameters, and functional and oncological outcomes. Descriptive statistics are presented. Results: Nineteen patients were identified; 18 (94.7%) completed the procedure robotically and one was converted to open surgery; 78.9% of patients had stage ≥IIB and 12 (63.2%) patients had undergone prior chemotherapy. The median operative time was 300 (interquartile range [IQR] 240-315) min. Median blood loss was 100 (IQR 50-175) mL. Median length of stay was 2 (range 1-11) days. All robotically completed patients commenced diet and passed flatus on Day 1 and were discharged by Day 3. The median lymph node yield was 40.5 (IQR 38-51) nodes. All patients undergoing nerve-sparing procedures recovered antegrade ejaculatory function. One patient had a Clavien-Dindo III complication (chylous ascites requiring drainage). At a median follow-up of 22.3 (IQR 16.3-24.9) months, one patient developed retroperitoneal recurrence, which was successfully treated with second-line chemotherapy; no other patients have had recurrences. Conclusion: Robotic retroperitoneal lymph node dissection is a safe and feasible alternative to open surgery in appropriately selected patients, offering low morbidity. Early oncological outcomes are promising. Larger cohorts and longer follow-ups are required to validate our institution's findings.
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Received: 25 July 2021
Available online: 20 January 2024
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Corresponding Authors:
*E-mail address: geo.mcc@gmail.com (G. McClintock).
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Port placement. The same port placement was used for left and right sided dissections. L, left arm; C, camera port; R, right arm; 4, 4th arm; A, assistant port.
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Demographic and tumour characteristic | Value | Agea at RPLND, year | 31 (25.5-37.5) | BMIa, kg/m2 | 27.5 (24.3-30.0) | ASA physical status classification systemb | 2 | 8 (42.1) | 3 | 11 (57.9) | Primary tumour lateralityb | Left | 12 (63.2) | Right | 6 (31.6) | Bilateral | 1 (5.3) | Histology on orchidectomyb,c | Seminoma | 2 (10.5) | NSGCT/mixed GCT | 15 (78.9) | Embryonal rhabdomyosarcoma | 1 (5.3) | Necrosis/no viable tumour | 2 (10.5) | Primary chemotherapyb | None | 7 (36.8) | One cycle (carboplatin) | 1 (5.3) | Three cycles BEP | 10 (52.6) | Four cycles BEP | 1 (5.3) | Pre-operative retroperitoneal tumour sizea, cm | 2.3 (0.9-12.0) | Pathological retroperitoneal tumour sizea, cm | 3.0 (1.3-7.0) | Pathological stageb | IIA | 4 (21.1) | IIB | 9 (47.4) | IIC | 6 (31.6) |
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Summary of baseline patient and tumour characteristics.
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Parameter | Value | Tumour locationa | Paraaortic | 11 (57.9) | Interaortocaval | 3 (15.8) | Paraaortic and interaortocaval | 4 (21.1) | Precaval | 1 (5.3) | Templatea | Modified left | 11 (57.9) | Modified right | 6 (31.6) | Bilateral | 2 (10.5) | Nerve sparea | Yes | 16 (84.2) | No | 3 (15.8) | Conversion to open surgerya | 1 (5.3) | Operative timebc, min | 300 (240-315) | Robotic console timebc, min | 215 (183-255) | Estimated blood lossb, mL | 100 (50-175) | Transfusion requireda | 0 (0) |
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Summary of tumour and operative characteristics.
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Parameter | Value | Length of staya, day | 1 | 3 (15.8) | 2 | 13 (68.4) | 3 | 2 (10.5) | 11 | 1 (5.3) | Opiate useb, mg of morphine equivalent | 52.5 (26.3-126.6) | Time to flatusb, day | 1 (1-1) | Readmission ratea | 0 (0) | Complicationa | | Clavien-Dindo Grade I | 0 (0) | Clavien-Dindo Grade II | | Open conversion with ileus | 1 (5.3) | Clavien-Dindo Grade III | | Chylous ascites requiring outpatient drainage | 1 (5.3) | Clavien-Dindo Grade IV or V | 0 (0) |
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Postoperative morbidity and complications.
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Functional and oncological outcomes | Value | Antegrade ejaculation recovery time in nerve-spare patientsa, week | 2.5 (1.8-4.5) | Lymph node count, na | 40.5 (38-51) | Node pathology, n (%) | Necrosis | 4 (21.1) | Teratoma only | 7 (36.8) | GCT with or without teratoma | 7 (36.8) | Embryonal rhabdomyosarcoma | 1 (5.3) | Follow-upa, month | 22.3 (16.3-24.9) | Recurrence, n (%) | In field | 1 (5.3) | Out of field | 0 (0) |
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Functional and oncological outcomes.
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