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Can we predict the incidence of high-grade Clavien-Dindo complications in patients with forgotten encrusted stents undergoing endourologic management? |
Praanjal Gupta,Ramanitharan Manikandan*( ),Lalgudi Narayanan Dorairajan,Kodakattil Sreenivasan Sreerag,Sidhartha Kalra,Swapnil Singh Kushwaha
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Department of Urology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India |
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Abstract Objective: Ureteral stents are customarily inserted to facilitate urinary drainage, but they come with their own glitches of being forgotten and/or encrusted leading to serious consequences. The present study aimed to report the complications in patients with forgotten and encrusted stents according to the Clavien-Dindo system specific to urological procedures and identify the factors leading to high-grade (Clavien-Dindo Grade 4A or above) complications. Methods: The hospital records of patients with forgotten encrusted double-J stents over a period of 8 years were reviewed. The parameters recorded included patient demographics, indwelling time, need for percutaneous nephrostomy, hemodialysis, urine culture, blood culture, total blood counts, serum creatinine, radiologic findings, management techniques, number of surgical interventions, modified Clavien-Dindo complications, follow-up, and mortality, if any. Results: Forty patients were included in the study. The median age was 52 (range 6-85) years. Of the total, 25 (62.5%) patients had a “significant” stent load; 31 (77.5%) had renal failure or acute kidney injury on presentation; 19 (47.5%) patients had sepsis at presentation. Among the patients presented with sepsis, 11 (57.9%) patients demonstrated a positive urine culture; and 7/11 (63.6%) patients exhibited pan-resistant organisms. Twelve out of 40 (30.0%) patients in our series developed high-grade Clavien-Dindo complications. On univariate analysis, sepsis at presentation (p=0.007), stent load (p=0.031), diabetes (p=0.023), positive urine culture (p=0.007), and stent indwelling time of more than 1 year (p=0.031) were found to be significant. On multivariate logistic regression analysis, sepsis at presentation (p=0.017) and positive urine culture (p=0.016) were significant predictors for high-grade complications. Conclusion: It is prudent to identify specific risk factors, namely sepsis at presentation and positive urine culture to triage and optimize these patients before surgical management.
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Received: 06 August 2021
Available online: 20 January 2024
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Corresponding Authors:
*E-mail address: minks_77@rediffmail.com (R. Manikandan).
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Category | Number (%) | Sex | Male | 32 (80.0) | Female | 8 (20.0) | Duration of encrustation | ≤1 year | 15 (37.5) | >1 year | 25 (62.5) | Degree of encrustation | Mild | 16 (40.0) | Moderate | 15 (37.5) | Severe | 9 (22.5) | Stent load | Insignificant | 15 (37.5) | Significant | 25 (62.5) | Preoperative renal failure or AKI | Absent | 9 (22.5) | Present | 31 (77.5) | Hemodialysis | Absent | 18 (45.0) | Present | 22 (55.0) | Comorbidity | Absent | 27 (67.5) | Present | 13 (32.5) | Sepsis at presentation | Absent | 21 (52.5) | Present | 19 (47.5) | Leukocyte count | Normal | 21 (52.5) | Abnormal | 19 (47.5) |
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Preoperative parameters assessed among the 40 patients with forgotten encrusted stents.
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Category | Number (%) | Number of surgical intervention | ≤2 | 21 (52.5) | >2 | 19 (47.5) | Transfusion requirement | Absent | 32 (80.0) | Present | 8 (20.0) | Culture sensitivity | Sterile | 19 (47.5) | Sensitive | 14 (35.0) | Pan-resistant | 7 (17.5) | Clavien-Dindo grade | 0 | 9 (22.5) | 1 | 15 (37.5) | 2 | 2 (5.0) | 3 | 2 (5.0) | ≥4A (high-grade) | 12 (30.0) | Treatment modality | ECIRS | 26 (65.0) | URSL | 7 (17.5) | URS and DJ removal | 3 (7.5) | PCNL | 2 (5.0) | Cystolitholapaxy | 1 (2.5) | Stented ESWL | 1 (2.5) |
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Perioperative parameters assessed among the 40 patients with forgotten encrusted stents.
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Method | p-Value | Univariate analysis | Sepsis at presentation | 0.007? | Stent load | 0.031? | Positive urine culture | 0.007? | Diabetes | 0.023? | Number of surgeries (>2) | 0.023? | Duration of the stent (>1 year) | 0.031? | Multivariate analysis | Sepsis at presentation | 0.017? | Positive urine culture | 0.016? | Number of surgeries (>2) | 0.067 |
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Predictors of high-grade Clavien-Dindo (≥4A) complications in patients with forgotten encrusted stents.
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[1] |
Lawrentschuk N, Russell JM. Ureteric stenting 25 years on: routine or risky? ANZ J Surg 2004; 74:243-7.
doi: 10.1111/j.1445-2197.2004.02947.x
pmid: 15043736
|
[2] |
Agarwal S, Sarpal R, Pathak P, Biswas M, Mittal A, Rathore K, et al. Tricks and tacks in the management of the forgotten double J stent. Int Surg J 2018; 5:792-5.
doi: 10.18203/2349-2902.isj20180447
|
[3] |
el-Faqih SR, Shamsuddin AB, Chakrabarti A, Atassi R, Kardar AH, Osman MK, et al. Polyurethane internal ureteral stents in treatment of stone patients: morbidity related to indwelling times. J Urol 1991; 146:1487-91.
doi: 10.1016/s0022-5347(17)38146-6
pmid: 1942324
|
[4] |
Mohan-Pillai K, Keeley Jr FX, Moussa SA, Smith G, Tolley DA. Endourological management of severely encrusted ureteral stents. J Endourol 1999; 13:377-9.
pmid: 10446801
|
[5] |
Divakaruni N, Palmer CJ, Tek P, Bjurlin MA, Gage MK, Robinson J, et al. Forgotten ureteral stents: who’s at risk? J Endourol 2013; 27:1051-4.
doi: 10.1089/end.2012.0754
pmid: 23590526
|
[6] |
Legrand F, Saussez T, Ruffion A, Celia A, Djouhri F, Musi G, et al. Double loop ureteral stent encrustation according to indwelling time: results of a European multicentric study. J Endourol 2021; 35:84-90.
doi: 10.1089/end.2020.0254
|
[7] |
Aron M, Ansari MS, Singh I, Gautam G, Kolla SB, Seth A, et al. Forgotten ureteral stents causing renal failure: multimodal endourologic treatment. J Endourol 2006; 20:423-8.
pmid: 16808657
|
[8] |
Sohrab A, Aneesh S, Sureka SK, Varun M, Nitesh P, Manoj K, et al. Forgotten reminders: an experience with managing 28 forgotten double-J stents and management of related complications. Indian J Surg 2015; 77:1165-71.
doi: 10.1007/s12262-015-1229-4
pmid: 27011530
|
[9] |
Ecke TH, Hallmann S, Ruttloff J. Multimodal stone therapy for two forgotten and encrusted ureteral stents: a case report. Cases J 2009; 2:106. https://doi.org/10.1186/1757-1626-2-106.
|
[10] |
Damiano R, Oliva A, Esposito C, De Sio M, Autorino R, D’Armiento M. Early and late complications of double pigtail ureteral stent. Urol Int 2002; 69:136-40.
doi: 10.1159/000065563
pmid: 12187045
|
[11] |
Leibovici D, Cooper A, Lindner A, Ostrowsky R, Kleinmann J, Velikanov S, et al. Ureteral stents: morbidity and impact on quality of life. Isr Med Assoc J 2005; 7:491-4.
pmid: 16106772
|
[12] |
Ilie VG, Ilie VI. Ureteric stent usedpart of the solution and part of the problem. Curr Urol 2018; 11:126-30.
doi: 10.1159/000447206
|
[13] |
Robert M, Boularan AM, El Sandid M, Grasset D. Double-J ureteric stent encrustations: clinical study on crystal formation on polyurethane stents. Urol Int 1997; 58:100-4.
pmid: 9096271
|
[14] |
Jain R, Chaparala H, Omar M, Ganesan V, Sivalingam S, Noble M, et al. Retained ureteral stents at a tertiary referral stone center-who is at risk? Urol Pract 2018; 5:452-7.
doi: 10.1016/j.urpr.2017.09.005
pmid: 37312366
|
[15] |
Abdelaziz AY, Fouda WB, Mosharafa AA, Abelrasoul MA, Fayyad A, Fawzi K. Forgotten ureteral stents: risk factors, complications and management. Afr J Urol 2018; 24:28-33.
doi: 10.1016/j.afju.2017.09.005
|
[16] |
Kram W, Buchholz N, Hakenberg OW. Ureteral stent encrustation. Pathophysiology. Arch Esp Urol 2016; 69:485-93.
|
[17] |
Wollin TA, Tieszer C, Riddell JV, Denstedt JD, Reid G. Bacterial biofilm formation, encrustation, and antibiotic adsorption to ureteral stents indwelling in humans. J Endourol 1998; 12: 101-11.
pmid: 9607434
|
[18] |
Tomer N, Garden E, Small A, Palese M. Ureteral stent encrustation: epidemiology, pathophysiology, management and current technology. J Urol 2021; 205:68-77.
doi: 10.1097/JU.0000000000001343
|
[19] |
Chung HS, Jung SI. Perioperative risk factors related to systemic inflammatory response syndrome after percutaneous nephrolithotomy. Urogenit Tract Infect 2019; 14: 9-13.
doi: 10.14777/uti.2019.14.1.9
|
[20] |
Vanderbrink BA, Rastinehad AR, Ost MC, Smith AD. Encrusted urinary stents: evaluation and endourologic management. J Endourol 2008; 22:905-12.
doi: 10.1089/end.2006.0382
pmid: 18643720
|
[21] |
Guner E, Seker KG. Comparison of two different scoring systems in encrusted ureteral stent management: a single-center experience. Urol J 2020; 17:248-51.
doi: 10.22037/uj.v0i0.5516
pmid: 32406053
|
[22] |
Manzo BO, Alarcon P, Lozada E, Ojeda J, Morales C, G?kce MI, et al. A novel visual-grading for ureteral encrusted stents classification to help decide the endourologic treatment. J Endourol 2021; 35:1314-9.
doi: 10.1089/end.2020.1225
|
[23] |
Adanur S, Ozkaya F. Challenges in treatment and diagnosis of forgotten/encrusted double-J ureteral stents: the largest single-center experience. Ren Fail 2016; 38:920-6.
doi: 10.3109/0886022X.2016.1172928
pmid: 27089423
|
[24] |
Aravantinos E, Gravas S, Karatzas AD, Tzortzis V, Melekos M. Forgotten, encrusted ureteral stents: a challenging problem with an endourologic solution. J Endourol 2006; 20:1045-9.
pmid: 17206899
|
[25] |
Thomas A, Cloutier J, Villa L, Letendre J, Ploumidis A, Traxer O. Prospective analysis of a complete retrograde ureteroscopic technique with holmium laser stent cutting for management of encrusted ureteral stents. J Endourol 2017; 31:476-81.
doi: 10.1089/end.2016.0816
pmid: 28292198
|
[26] |
de la Rosette J, Assimos D, Desai M, Gutierrez J, Lingeman J, Scarpa R, et al. The Clinical Research Office of the Endourological Society percutaneous nephrolithotomy global study: indications, complications, and outcomes in 5803 patients. J Endourol 2011; 25:11-7.
doi: 10.1089/end.2010.0424
pmid: 21247286
|
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