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| Primary unifocal penile follicular center non-Hodgkin lymphoma: Report of a rare case and review of the literature |
Nikolaos Kostakopoulosa,*( ),Christos Masaoutisb,Vasileios Argyropoulosa,Varvara Pantelaionc,Panagiotis Theodoropoulosd,Panagiotis Kouroupakise,Athanasios Kostakopoulosa
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a1st Department of Urology, Metropolitan General Hospital, Athens, Greece
bDepartment of Pathology, Metropolitan General Hospital, Athens, Greece
cDepartment of Pathology, Evangelismos General Hospital of Athens, Greece
d2nd Department of Surgery, Evangelismos General Hospital of Athens, Greece
eDepartment of Haematology, Sismanogleio General Hospital, Athens, Greece |
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Received: 15 December 2022
Available online: 20 January 2024
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Corresponding Authors:
*E-mail address: nikostakop@gmail.com (N. Kostakopoulos)
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The results of the hematoxylin and eosin stain, immunohistochemistry, and FISH. (A) The hematoxylin and eosin stain results: a dense, vaguely nodular lymphoid infiltrate occupying the dermis, composed of small-to-medium sized cells with slightly irregular nuclear contours; (B-F) Immunohistochemistry results: extensively expressed B-cell marker (CD20) in lymphatic infiltration (B), the expression of the germinal center marker (BCL6) in a nodular and diffuse manner (C and D), and the implied expression of BCL2 (E) on the B-cells when juxtaposed to CD3 immunostaining (F); (G and H) The results of FISH: fluorescent results with the break-apart probes for the BCL2 gene, consistent with BCL2 rearrangements (G), and magnified FISH of multiple split signals (yellow arrows), consistent with BCL2 rearrangements (H). FISH, fluorescent in situ hybridization.
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