First report of the histopathological effect of electrocautery using on the urethral taste rosea during glans penis injury by incision in rabbits

doi:10.1016/j.ajur.2022.03.004

Asian Journal of Urology, 2024, 11 (1): 115-120 doi: 10.1016/j.ajur.2022.03.004

Original Articles

First report of the histopathological effect of electrocautery using on the urethral taste rosea during glans penis injury by incision in rabbits

Ozgur Caglar^a,Ayhan Kanat^b,*(

),Mehmet Dumlu Aydin^c,Nezih Akca^d,Sevilay Ozmen^e

^aAtaturk University, Medical Faculty, Department of Pediatric Surgery, Erzurum, Turkey
^bRecep Tayyip Erdogan University, Medical Faculty, Department of Neurosurgery, Rize, Turkey
^cAtaturk University, Medical Faculty, Department of Neurosurgery, Erzurum, Turkey
^dRecep Tayyip Erdogan University, Medical Faculty, Department of Urology, Rize, Turkey
^eAtaturk University, Medical Faculty, Department of Pathology, Erzurum, Turkey

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Abstract

Objective: Currently, electrocautery devices have frequently been used in penile surgical procedures. We hypothesized that electrocautery using during penile surgical procedures may harm the taste rosea and the dorsal nerve of the penis or clitoris.

Methods: Eighteen young age male New Zealand rabbits were studied: five in the control (Group I, n=5), five in the penile surgery without using electrocautery (sham group, Group II, n=5), eight in the monopolar cautery (study group, Group III, n=8) groups under general anesthesia. The animals were followed for 3 weeks and sacrificed. Penile tissue—pudendal nerve root complexes and dorsal root ganglion of sacral 3 level were examined using stereological methods. The results were compared statistically.

Results: The live and degenerated taste bud-like structures and degenerated neuron densities of pudendal ganglia (mean±standard deviation, n/mm³) were estimated as 198±24/mm³, 4±1/mm³, and 5±1/mm³ in Group I; 8±3/mm³, 174±21/mm³, and 24±7/mm³ in Group II; and 21±5/mm³, 137±14/mm³, and 95±12/mm³ in Group III, respectively. Neurodegeneration of taste buds and pudendal ganglia was significantly different between groups.

Conclusion: Intact spinal cord and normal parasympathetic and thoracolumbar sympathetic networks are crucial for human sexual function. The present study indicates that the glans penis injury by using electrocautery may lead to pudendal ganglia degeneration. Iatrogenic damage to taste rosea and retrograde degeneration of the pudendal nerve may be the cause of sexual dysfunction responsible mechanism.

Key words： Urethral taste rosea Taste buds Pudendal nerve Degeneration Penile surgery

Received: 27 June 2021 Available online: 20 January 2024

Corresponding Authors: *E-mail address: ayhankanat@yahoo.com (A. Kanat).

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	Sevilay Ozmen

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Ozgur Caglar,Ayhan Kanat,Mehmet Dumlu Aydin, et al. First report of the histopathological effect of electrocautery using on the urethral taste rosea during glans penis injury by incision in rabbits[J]. Asian Journal of Urology, 2024, 11(1): 115-120.

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http://www.ajurology.com/EN/10.1016/j.ajur.2022.03.004 OR http://www.ajurology.com/EN/Y2024/V11/I1/115

Histopathology of the effect of electrocautery. (A) Sacral spinal cord including ON (LM, GFAP, 4×); (B) S2 DRG with normal and degenerated ganglion cell and S2 NR (LM, H & E, 4×); (C) S2 DRG with deformed neurons, NR, and spinal cord of an animal in whom electrocautery was applied during penile incision (LM, GFAP, 4x). ON, Onuf's nucleus; GFAP, glial fibrillary acidic protein; LM, light microscopy; DRG, dorsal root ganglion; NR, nerve root; H & E, hematoxylin and eosin; S2, sacral 2; SC, spinal cord.

Changes of histopathologic view of urethral taste roseas. (A) Urethral taste buds or normal taste bud-like structures named as taste roseas (yellow arrows, LM, H & E, 10×); (B) Intraluminal scattered located taste rosea (blue arrow, LM, gustducin, 40×); (C) the DTR after application of electrocautery during penile incision in an animal of the study group (green arrow, LM, gustducin, 40×). DTR, degenerated taste rosea; LM, light microscopy; H & E, hematoxylin and eosin.

The values of taste bud-like structures (n/mm³).

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