Expanding luminal epitheliums as cells of origin for prostate cancer
Yuexi Guab*(),Gong-Hong Weiabc*()
a Fudan University Shanghai Cancer Center, Department of Biochemistry and Molecular Biology, School of Basic b Medical Sciences, Shanghai Medical College of Fudan University, Shanghai, China c Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland
. [J]. Asian Journal of Urology, 2021, 8(2): 238-240.
Yuexi Gu,Gong-Hong Wei. Expanding luminal epitheliums as cells of origin for prostate cancer. Asian Journal of Urology, 2021, 8(2): 238-240.
Guo W, Li L, He J, Liu Z, Han M, Li F, et al. Single-cell transcriptomics identifies a distinct luminal progenitor 1 cell type in distal prostate invagination tips. Nat Genet 2020; 52:908e18.
[2]
Karthaus WR, Hofree M, Choi D, Linton EL, Turkekul M, Bejnood A, et al. Regenerative potential of prostate luminal cells revealed by single-cell analysis. Science 2020; 368:497e505.
[3]
Arendt D, Musser JM, Baker CVH, Bergman A, Cepko C, Erwin DH, et al. The origin and evolution of cell types. Nat Rev Genet 2016; 17:744e57.
[4]
Blanpain C. Tracing the cellular origin of cancer. Nat Cell Biol 2013; 15:126e34.
[5]
Li JJ, Shen MM . Prostate stem cells and cancer stem cells. Cold Spring Harb Perspect Med 2019;9:a030395. https://doi.org/10.1101/cshperspect.a030395.
[6]
Goldstein AS, Huang J, Guo C, Garraway IP, Witte ON. Identification of a cell-of-origin for human prostate cancer. Science 2010; 329:568e71.
[7]
Wang Z, Mitrofanova A, Bergren SK, Abate-Shen C, Cardiff RD, Califano A, et al. Lineage analysis of basal epithelial cells reveals their unexpected plasticity and supports a cell-oforigin model for prostate cancer heterogeneity. Nat Cell Biol 2013; 15:274e83.
[8]
Tirosh T, Suva ML . Deciphering human tumor biology by single-cell expression profiling. Annu Rev Canc Biol 2019; 3:151e66.
[9]
Kwon OJ, Zhang L, Xin L. Stem cell antigen-1 identifies a distinct androgen-independent murine prostatic luminal cell lineage with bipotent potential. Stem Cell 2016; 34:191e202.
[10]
Tata PR, Mou H, Pardo-Saganta A, Zhao R, Prabhu M, Law BM, et al. Dedifferentiation of committed epithelial cells into stem cells in vivo. Nature 2013; 503:218e23.
