Non-seminomatous germ cell tumor with bone metastasis only at diagnosis: A rare clinical presentation
K. C. Biebighausera, Jianjun Gaob, Priya Raoc, Gene Landonc, Lance Pagliarod, Colin P. N. Dinneye, Jose Karame, Neema Navaie
a The University of Texas Medical School at Houston, Houston, TX, USA; b Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; c Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; d Division of Medical Oncology, Department of Oncology, Mayo Clinic, Rochester, MN, USA; e Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Non-seminomatous germ cell tumor with bone metastasis only at diagnosis: A rare clinical presentation
K. C. Biebighausera, Jianjun Gaob, Priya Raoc, Gene Landonc, Lance Pagliarod, Colin P. N. Dinneye, Jose Karame, Neema Navaie
a The University of Texas Medical School at Houston, Houston, TX, USA; b Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; c Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; d Division of Medical Oncology, Department of Oncology, Mayo Clinic, Rochester, MN, USA; e Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
摘要 Bone metastasis of non-seminomatous germ cell tumors (NSGCT) of the testes is a rare event and even more uncommon at initial presentation. Generally, bone lesions are discovered in the presence of concurrent retroperitoneal lymph node or visceral disease. However, in this case, a 37 years old male complaining of a growing testicular mass was found to have isolated bone metastasis with associated caudaequina syndrome without apparent abnormal findings on initial computed tomography (CT) scans. Continued neurologic symptoms prompted further evaluation with magnetic resonance imaging (MRI), which demonstrated multiple sites of bone metastasis without evidence of retroperitoneal lymph node or visceral organ involvement. This case represents a rare clinical presentation and disease manifestation of NSGCT.
Abstract: Bone metastasis of non-seminomatous germ cell tumors (NSGCT) of the testes is a rare event and even more uncommon at initial presentation. Generally, bone lesions are discovered in the presence of concurrent retroperitoneal lymph node or visceral disease. However, in this case, a 37 years old male complaining of a growing testicular mass was found to have isolated bone metastasis with associated caudaequina syndrome without apparent abnormal findings on initial computed tomography (CT) scans. Continued neurologic symptoms prompted further evaluation with magnetic resonance imaging (MRI), which demonstrated multiple sites of bone metastasis without evidence of retroperitoneal lymph node or visceral organ involvement. This case represents a rare clinical presentation and disease manifestation of NSGCT.
K. C. Biebighauser, Jianjun Gao, Priya Rao, Gene Landon, Lance Pagliaro, Colin P. N. Dinney, Jose Karam, Neema Navai. Non-seminomatous germ cell tumor with bone metastasis only at diagnosis: A rare clinical presentation[J]. Asian Journal of Urology, 2017, 4(2): 124-127.
K. C. Biebighauser, Jianjun Gao, Priya Rao, Gene Landon, Lance Pagliaro, Colin P. N. Dinney, Jose Karam, Neema Navai. Non-seminomatous germ cell tumor with bone metastasis only at diagnosis: A rare clinical presentation. Asian Journal of Urology, 2017, 4(2): 124-127.
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