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| Metabolic syndrome and benign prostatic hyperplasia:An update |
| Ho-Yin Ngaia, Kar-Kei Steffi Yuena, Chi-Man Nga, Cheung-Hing Chengb, Sau-Kwan Peggy Chub
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a Division of Urology, Department of Surgery, Queen Elizabeth Hospital, Hong Kong, China;
b Division of Urology, Department of Surgery, Tuen Mun Hospital, Hong Kong, China |
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Abstract Metabolic syndrome (MetS) is a cluster of metabolic abnormalities related to central adiposity and insulin resistance. Its importance is increasingly recognized as it associates with increased risks of metabolic and cardiovascular diseases. These metabolic aberrations of MetS may lead to development of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS) in men. A 26.5%-55.6% prevalence of MetS in men with LUTS was reported in worldwide studies. Although the exact biological pathway is not clear yet, insulin resistance, increased visceral adiposity, sex hormone alterations and cellular inflammatory reactions played significant roles in the related pathophysiological processes. Clinician should recognize the cardiovascular and metabolic impacts of MetS in men with LUTS, early risk factors optimization and use of appropriate medical therapy may possibly alter or slower the progression of LUTS/BPH, and potentially avoid unnecessary morbidities and mortalities from cardiovascular and metabolic diseases for those men.
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Received: 29 September 2016
Published: 26 August 2017
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Corresponding Authors:
Ho-Yin Ngai,E-mail address:ngaiho@ha.org.hk.
E-mail: ngaiho@ha.org.hk
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